![]() Sarna SK: Physiology and pathophysiology of colonic motor activity (part one of two). J Gastrointest Motil 3(1):12–18, 1991Īlvarez WC: Functional variations in contractions of different parts of the small intestine. 322Īrouni MA, Lof J, Jacobs DL, Rikkers LF, Quigley EMM: Studies of small intestinal myoelectrical activity and intraluminal pressure changes in the unrestrained conscious rat. Biometrics 12:307–310, 1956ĭavies RG: Computer Programming in Quantitative Biology, Nonparametric Statistics, London, Academic Press, 1971, p. Kramer CY: Extension of multiple range test to groups with unequal numbers of replications. Gastroenterology 73:23–27, 1977ĭixon WJ, Massey FJ: Introduction to Statistical Analysis. Am J Dig Dis 16:706–708, 1971Īrndorfer RC, Stef JJ, Dodds WJ, Linehan JH, Hogan ME, Hogan WJ: Improved infusion system for intraluminal esophageal manometry. J Physiol 31:272–304, 1904Įdwards DH, Beck ER: Fecal flow, mixing and consistency. Swed J Agric Res 13:243–256, 1983Įlliot TR, Barclay-Smith E: Antiperistalsis and other muscular activity of the colon. Sperber I, Bjornhag G, Ridderstrahle Y: Function of proximal colon in lemming and rat. In Mediators and Drugs in Gastrointestinal Motility. Br J Pharmacol 101:1011–1015, 1990īaumgarten HG: Morphological basis of gastrointestinal motility: Structure and innervation of gastrointestinal tract. ![]() Hata F, Kataoka T, Takeushi T, Yagosaki O, Yamano N: Differences in control of descending inhibition in the proximal and distal regions of rat colon. We conclude that 5HT 1A agonists such as 8-OH-DPAT may promote defecation and occurrence of propulsive waves through the same serotoninergic mechanism.įerré JP, Ruckebush Y: Myoelectrical activity and propulsion in the large intestine of fed and fasted rats. The serotonin 5HT 1A agonist 8-OH-DPAT dramatically and dose-dependently increased the frequency of long-duration, high-amplitude waves in the transverse and distal colon, and concurrently promoted defecation these effects were prevented by the putative 5HT 1A antagonist pindolol. Pressure waves in control rats reflected two types of motor activity: short-duration waves (15 sec, >15 mm Hg) that occurred only occasionally (1/hr or less) in the transverse and distal, but not in the proximal colon these waves appeared to migrate aborally and were associated with defection. ![]() A manometric low compliance perfusion system, which was set at a very low flow rate (0.03 ml/min), permitted simultaneous recordings of intraluminal pressure in the proximal, transverse, and distal colon. We investigated in conscious and unrestrained rats, the major patterns of colonic pressure waves, as related to defecation.
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